• The present work lays the groundwork for reactor engineering

  2020-08-04

  

  The present work lays the groundwork for reactor engineering, required for proper scaling of synthesis. An enzyme’s kinetic mechanism (the order and manner of substrate binding and product release) determines its kinetic rate law. The rate law defines the turnover rate as a function of substrate con

• On the other hand the

  2020-08-03

  

  On the other hand, the IL-8 promoter activity induced by the signalling cascade of the CysLT1-G300S receptor is higher than that of the WT receptor. The chemokine IL-8 is mainly involved in the recruitment and activation of neutrophils and we have previously shown that this chemokine gene is a targe

• br Acknowledgments This work was supported in part

  2020-08-03

  

  Acknowledgments This work was supported in part by the Japan Society for the Promotion of Science (JSPS) Grants-in-Aid for Scientific Research, KAKENHI; the Funding Program for Next Generation World-Leading Researchers, Grant No. LS081 (H.H.); Research Fellowships for Young Scientists (Y.O. and R

• br Talasiu site The Talasiu site

  2020-08-03

  

  Talasiu site The Talasiu site (TO-Mu-2) is located on the palaeoreef-limestone shoreline of the Fanga ‘Uta Lagoon, north of Lapaha Village, only 2.5 km south of Nukuleka Village which is regarded as the place of the initial Lapita landfall in Tonga (Burley et al., 2010) (Fig. 1). The site consist

• Of particular interest are findings indicating that an

  2020-08-03

  

  Of particular interest are findings indicating that an intact NE system is necessary for the action of multiple anticonvulsant therapies. For example, lesions of the locus coeruleus (LC), the major NE nucleus in the brain, attenuate the effects of multiple anticonvulsant drugs, including carbemazepi

• br Introduction A pretreatment technique

  2020-08-03

  

  Introduction A pretreatment technique named porous membrane protected micro-solid-phase extraction (μ-SPE) was proposed by Basheer et al. in 2006 [1]. It is based on the packing of small amount of sorbent material in a sealed porous membrane envelope. Compared to other pretreatment techniques, th

• The relatively low overall response rates suggest

  2020-08-03

  

  The relatively low overall response rates suggest the need for better predictive markers for response. The patient demographics in the SARC trial did not reflect typical Ewing sarcoma demographics as the patients tended to be older and had primarily soft tissue tumors. In addition, although accrual

• In this study we make the novel observation

  2020-08-03

  

  In this study we make the novel observation that villin-1 and gelsolin are down-regulated in response to diverse cellular stressors, including bacteria associated with the pathogenesis of CD. The high plasticity and dynamics of the BRD-K4477 cytoskeleton are exploited by bacterial and viral pathoge

• br Materials and methods br Results br Discussion

  2020-08-03

  

  Materials and methods Results Discussion Previously, we reported the identification of a mutation, G469E, in a LIG4 syndrome patient which severely impacts upon DNA ligase IV function [5]. Closer examination of the sequence in the vicinity of G469 revealed a motif, designated Va, that is we

• So far both DGAT and have been found in

  2020-08-03

  

  So far, both DGAT1 and 2 have been found in various living organisms [6], [24], but there are very few studies on DGATs in microalgae in spite of the availability of increasing full genomic sequences of microalgae. For example, PtDGAT1 from the diatom Phaeodactylum tricornutum is the only algal DGA

• We found that both DDR and DDR ECD

  2020-08-03

  

  We found that both DDR1 and DDR2 ECD increased matrix mineralization as compared to native cells, with the effect of DDR2 ECD being more prominent. Both soluble (DDR2/ECD) and membrane-bound DDR2 ECD (DDR2/-KD), when compared to wild-type cells, induced larger mineral deposits. In this regard, a rec

• In some fish a rise in

  2020-07-31

  

  In some fish a rise in plasma progesterone (P4) levels and changes of mPR abundance in gonads were reported to be associated with oocyte maturation and ovulation (Kagawa et al., 1981, Kazeto et al., 2005b) and sperm mobility is also regulated by non-genomic progesterone actions in fish and mammals (

• br Estrogen receptor ligand independent signaling An interes

  2020-07-31

  

  Estrogen receptor ligand independent signaling An interesting phenomenon observed in many cells is that estrogen receptors can actually be activated in the absence of estrogens or other receptor agonists (Bennesch & Picard, 2015; Maggi, 2011; Vrtačnik et al., 2014). This ligand-independent estrog

• We recently employed a functional drug screening

  2020-07-31

  

  We recently employed a functional drug screening approach to identify mithramycin as an inhibitor of EWS–FLI1. In our study, we employed a stepwise approach involving a luciferase primary screen and a novel multiplex PCR screen to evaluate over 50,000 compounds to identify mithramycin as an inhibito

• Introduction Obesity constitutes a global healthcare problem

  2020-07-31

  

  Introduction Obesity constitutes a global healthcare problem and has many adverse effects on the cardiovascular function [1,2]. Recently, the perivascular adipose tissue (PVAT) has emerged as a relevant fat depot for cardiovascular risk and as a potential trigger in vascular dysfunction. Indeed, PV

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